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Updated: Sep 25, 2026

Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice
Published on: December 8, 2023
Infusion of donor-derived hematopoietic stem cells in organ transplantation: clinical data
Luc De Pauw1, Michel Toungouz, Michel Goldman
1Nephrology Department, Hôpital Erasme, Brussels, Belgium. ludepauw@ulb.ac.be
Abstract:
Many strategies for tolerance induction have been developed, because this is the major goal of clinical transplantation. One of the most effective and best-studied approaches has been based on the injection of hematopoietic cells derived from the donor bone marrow, to establish a state of microchimerism in the recipient. A subset of hematopoietic stem cells might be responsible for the tolerogenic properties. These CD34+ bone marrow stem cells can be isolated and safely injected into kidney transplant recipients. In the authors' clinical trial, no adverse effects were observed, and the infusion of donor CD34+ cells was well tolerated.
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