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Cardiovascular disease risk factors in HIV patients--association with antiretroviral therapy. Results from the DAD

Nina Friis-Møller1, Rainer Weber, Peter Reiss

  • 1DAD Coordinating Centre, Copenhagen HIV Programme, Hvidovre University Hospital, Copenhagen, Denmark. nfm@cphiv.dk

AIDS (London, England)
|June 24, 2003
PubMed

Insights

HIV-infected individuals have numerous cardiovascular disease risk factors. Certain antiretroviral therapies, particularly protease inhibitors and non-nucleoside reverse transcriptase inhibitors, are linked to higher cholesterol levels, increasing heart disease risk.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Cardiovascular disease (CVD) is a significant concern in HIV-infected populations.
  • Understanding CVD risk factors in this demographic is crucial for effective management.

Purpose of the Study:

  • To determine the prevalence of CVD risk factors in HIV-infected individuals.
  • To investigate associations between these risk factors, HIV disease stage, and antiretroviral therapy (ART) use.

Main Methods:

  • Analysis of baseline data from 17,852 subjects in the DAD prospective multinational cohort study.
  • Cross-sectional assessment of demographic variables, smoking, diabetes, hypertension, dyslipidemia, BMI, HIV stage, and ART use.

Main Results:

  • Over 25% of the population were in an age group with appreciable CVD risk.
  • Elevated total cholesterol was significantly associated with protease inhibitor (PI) and/or non-nucleoside reverse transcriptase inhibitor (NNRTI) use compared to ART-naive subjects.
  • Higher CD4 cell count, lower HIV RNA, lipodystrophy, longer PI/NNRTI exposure, and older age were linked to elevated cholesterol.

Conclusions:

  • HIV-infected individuals present with multiple CVD risk factors.
  • Use of NNRTI and PI drug classes, especially in combination, is associated with adverse lipid profiles, increasing coronary heart disease risk, particularly in older individuals with controlled HIV.
Abstract

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