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Updated: Jul 19, 2026

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
Published on: March 23, 2011
Relative sparing of nitric oxide synthase-containing neurons in the hippocampal formation in Alzheimer's disease
B T Hyman1, K Marzloff, J J Wenniger
1Neurology Service, Massachusetts General Hospital, Boston 02114.
Abstract:
Nitric oxide (NO) is an endogenous neuromodulator that may mediate neurotoxic effects of glutamate. NO-synthesizing neurons are, however, resistant to NO- and glutamate-induced neurotoxicity. We now show that NO synthase neurons are selectively spared in patients with Alzheimer's disease, even in a severely affected region of the brain such as the hippocampal formation.
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