Related Experiment Video
Updated: Jul 21, 2026

The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse
Published on: July 25, 2011
Role of free radical reactions in ischemic brain injury
1Cerebral Vascular Disease Research Center, Dept. of Neurology, University of Miami School of Medicine, Miami, Florida 33101, USA.
Abstract:
Free radical reactions figure prominently in ischemic brain injury by inducing lipid peroxidation and damage to DNA and proteins. Several research areas have attracted recent attention, including the pathophysiological roles of nitric oxide (NO) radical and the peroxynitrite anion, formed by the reaction of NO with superoxide; the vulnerability of mitochondria to oxidative injury; and the relevance of both vascular sites (e.g., endothelial injury, neutrophil activation and secretion of radical species) and parenchymal sites of radical-mediated injury. A variety of biomarkers have been validated for the detection of radical products and radical-mediated injury to lipids, DNA and proteins. Pharmacological advances in antioxidant therapy include the development of novel nitrone-based spin trap agents with neuroprotective properties. Human serum albumin in moderate-to-high doses has been shown to be strikingly neuroprotective in brain ischemia, and its effects may be mediated by antioxidant mechanisms. The use of transgenic and knockout mutant mice has proved enormously useful in elucidating oxidant injury mechanisms in cerebral ischemia.
More Related Videos
Related Concept Videos
Radical Formation: Overview
Radicals from spin-paired molecules:
Radicals can be obtained from spin-paired molecules either by homolysis or electron transfer. While two radicals are formed in the former, an electron is added in the latter, also known...
Radical Formation: Addition
Similar to charge conservation in chemical reactions, spin conservation is implicit for radical reactions. Accordingly, the product formed must possess an unpaired...
Radical Reactivity: Overview
Radical Autoxidation
Ischemic Stroke l: Introduction
Ischemic Stroke ll: Pathophysiology

