Alpha(v)beta(3) integrin in angiogenesis and restenosis

Area of Science:

• Molecular biology
• Pathology
• Pharmacology

Background:

• Integrins are implicated in various diseases, including cancer, cardiovascular diseases, and inflammatory conditions.
• The precise mechanisms of integrin involvement in disease are under investigation.
• Therapeutic strategies targeting integrins are emerging.

Purpose of the Study:

• To review the critical role of alpha(v) integrin (alpha(v)beta(3)) in disease-related angiogenesis.
• To highlight therapeutic candidates that modulate integrin function.

Main Methods:

• Literature review of studies on integrins and disease.
• Focus on alpha(v)beta(3) integrin's function in angiogenesis.
• Analysis of therapeutic approaches including antibodies, peptides, and peptidomimetics.

Main Results:

• Alpha(v)beta(3) integrin is central to angiogenesis in cancer, restenosis, stroke, ocular diseases, and rheumatoid arthritis.
• Various therapeutic agents have demonstrated efficacy in modulating disease processes by targeting integrins.

Conclusions:

• Alpha(v)beta(3) integrin is a significant therapeutic target for a range of diseases.
• Targeted therapies offer potential for managing angiogenesis-driven pathologies.