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Interleukin 1 receptor antagonist (IL-1RA) polymorphism in women with cervical cancer
Alexander Mustea1, Jalid Sehouli, Dominique Könsgen
1Charité, Department of Obstetrics and Gynaecology, Humboldt University, Augustenburger Platz 1, D-13353 Berlin, Germany. amustea@yahoo.com
Background:
Several studies suggest that immunological components play a key role in the development of cervical cancer. Polymorphism in the IL-1 RA gene was associated with various malignant diseases. Data is lacking for cervical cancer.
Materials And Methods:
In a prospective study we analysed the polymorphism of IL-1RA in 113 women with cervical cancer and 107 with benign diseases. Genomic DNA fragments were amplified by PCR.
Results:
The distribution of genotype frequencies was different between the study and control group with respect to allele 2 heterozygotes (24.8% vs. 13.1%; p = 0.04) but not in the frequencies of allele 1/3 and homozygous allele 2. There were no differences between IL-1 RA 1/2 polymorphism and all other alleles in tumour stage, grading, recurrence status and age.
Conclusion:
This data supports the role for allele 2 of the gene encoding for IL1-RA as a genetic determinant of cervical cancer.
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