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Detection of Functional Matrix Metalloproteinases by Zymography
Published on: November 9, 2010
Matrix-metalloproteinases in Hodgkin lymphoma
C Thorns1, H W Bernd, D Hatton
1Institute of Pathology, University of Luebeck, German Consultation and Reference Centre for Lymphomas, Germany. thorns@patho.mu-luebeck.de
Anticancer Research
|June 25, 2003
Summary
This study reveals a complex interplay of metalloproteinases in classical Hodgkin lymphomas. Tumor cells expressing EMMPRIN may drive MMP-2 in bystander cells, suggesting therapeutic targets.
Area of Science:
- Oncology
- Cancer Biology
- Immunohistochemistry
Background:
- Classical Hodgkin lymphomas (CHL) feature sparse tumor cells and abundant reactive cells.
- Morphological characteristics suggest a role for tumor-microenvironment interactions in CHL pathogenesis.
Purpose of the Study:
- To investigate the expression of EMMPRIN and matrix metalloproteinases (MMPs) in CHL.
- To explore the potential interactions between tumor cells and bystander cells involving MMPs.
Main Methods:
- Immunohistochemistry was used to analyze EMMPRIN, MMP-2, MMP-7, MMP-9, MMP-10, and MMP-11 expression.
- The study included 34 cases of classical Hodgkin lymphomas.
Main Results:
- Tumor cells were positive for EMMPRIN (100%).
- Hodgkin and Reed-Sternberg (HRS) cells were mostly negative for MMP-2, while surrounding cells were positive (71%).
- HRS cells expressed MMP-7 (68%), and surrounding cells showed MMP-2 and MMP-9 positivity, suggesting a complex MMP network.
Conclusions:
- A complex interaction exists between CHL tumor cells and bystander cells concerning metalloproteinases.
- EMMPRIN expression in tumor cells may induce MMP-2 in surrounding cells, potentially activated by tumor cell-expressed MMP-7.
- Targeting this metalloproteinase interaction cycle could offer therapeutic benefits.
