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The AbioCor implantable replacement heart.

Robert D Dowling1, Laman A Gray, Steven W Etoch

  • 1Department of Surgery, Division of Thoracic and Cardiovascular Surgery, University of Louisville School of Medicine, Louisville, Kentucky, USA. rddowl01@ahtena.louisville.edu

The Annals of Thoracic Surgery
|June 25, 2003
PubMed
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The AbioCor implantable replacement heart (IRH) offers a potential therapy for end-stage heart failure. Early trials show patient discharge and no device malfunctions, though stroke risk requires further investigation.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Surgery
  • Medical Devices

Background:

  • Severe biventricular failure necessitates advanced therapeutic options.
  • The AbioCor implantable replacement heart (IRH) is a novel, totally implantable artificial heart.
  • Patients unsuitable for transplantation were evaluated for this trial.

Observation:

  • A multicenter trial assessed the AbioCor IRH in high-mortality patients.
  • Surgical implantation involved orthotopic placement of the thoracic unit.
  • Post-operative monitoring identified intraoperative and late deaths, with autopsies revealing thrombus on atrial struts.

Findings:

  • Two intraoperative deaths occurred; four late deaths were recorded, including three cerebrovascular accidents.

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  • Three patients demonstrated significant recovery, with one discharged home for over seven months.
  • No significant device malfunctions or device-related infections were observed.

    • Implications:

    • The AbioCor IRH shows promise as an effective therapy for end-stage heart failure.
    • Addressing thrombus formation on atrial struts may mitigate cerebrovascular accident risk.
    • Successful patient discharge signifies a major milestone in artificial heart technology.