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Updated: Sep 25, 2026
Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease
Published on: May 22, 2026
Tissue Doppler analysis is hindered in abnormal wall motion and changes in afterload
Silvana Müller1, Thomas Bartel, Joop Koopman
1Department of Cardiology, University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria. silvana.mueller@uibk.ac.at
Background:
Tissue Doppler (TD) analysis is used to estimate contractility. However, interference with hemodynamics has not been investigated.
Objective:
To evaluate the effect of hemodynamic conditions and wall motion abnormalities on TD indices.
Methods:
TD indices were obtained in 16 dogs and correlated with hemodynamics and wall thickening.
Results:
An inverse relation between TD indices and systemic vascular resistance was observed when afterload-related parameters were included in the analysis (early systolic subendocardial velocity: r((multiple regression))=0.82, P<0.0001 vs. r((simple regression))=0.57, P=0.0002). Early systolic TD data were more closely related to hemodynamics than those derived from the entire systole. TD data did not correspond to the hyperkinesia of the contralateral wall in myocardial infarction, whereas the increase of gradient parameters reflected hypercontractility (P<0.05).
Conclusion:
TD indices are directly related to contractility and inversely to afterload. They do not reflect wall motion of those segments not involved in regional ischemia.
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