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Tissue Doppler analysis is hindered in abnormal wall motion and changes in afterload
Silvana Müller1, Thomas Bartel, Joop Koopman
1Department of Cardiology, University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria. silvana.mueller@uibk.ac.at
International Journal of Cardiology
|June 25, 2003
Summary
Tissue Doppler (TD) indices reflect cardiac contractility but are influenced by hemodynamics. TD analysis does not accurately assess wall motion in ischemic regions, highlighting limitations in its interpretation.
Area of Science:
- Cardiovascular Physiology
- Echocardiography
- Cardiac Mechanics
Background:
- Tissue Doppler (TD) analysis is a standard method for estimating myocardial contractility.
- The impact of hemodynamic conditions on TD indices has not been thoroughly investigated.
Purpose of the Study:
- To evaluate the influence of hemodynamic status on TD indices.
- To assess the effect of wall motion abnormalities on TD measurements.
Main Methods:
- TD indices were acquired in a canine model (n=16).
- Measurements were correlated with hemodynamic parameters and regional wall thickening.
- Analysis included assessment of early systolic and entire systolic TD data.
Main Results:
- A significant inverse relationship was found between TD indices and systemic vascular resistance when afterload was considered (multiple regression analysis).
- Early systolic TD indices showed a stronger correlation with hemodynamic conditions compared to those derived from the entire systole.
- TD indices did not accurately reflect hyperkinesia in contralateral walls of myocardial infarction models; gradient parameters better indicated hypercontractility.
Conclusions:
- TD indices are influenced by both myocardial contractility and afterload.
- TD analysis may not reliably assess wall motion in myocardial segments unaffected by regional ischemia.