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Published on: February 12, 2017
Treatment of recurrent cervical adenocarcinoma with BMS-247550, an epothilone B analog
Manish Agrawal1, Maureen Edgerly, Tito Fojo
1Center for Cancer Research, National Cancer Institute Building 10/12C103, 9000 Rockville Pike, Bethesda, MD 20892, USA.
Objective:
The incidence of recurrent cervical adenocarcinoma is rising relative to the squamous subtype. There are limited therapeutic options for women with advanced cervical adenocarcinoma. Only a few chemotherapy agents have demonstrated activity in this disease. This report describes results with BMS-247550, an epothilone B analog that stabilizes microtubules, with activity in previously treated adenocarcinoma of the cervix.
Method:
We present two women with recurrent cervical adenocarcinoma with metastases to the lung. Both women were treated previously with paclitaxel and were enrolled in a phase I study with BMS-247550. Both women had partial responses to BMS-247550 with a decrease in tumor size and CA-125 levels.
Conclusions:
The demonstration of a response to BMS-247550, especially after additional chemotherapy had been administered, is encouraging, albeit preliminary. The ultimate role of BMS-247550 and multiagent chemotherapy in the treatment of adenocarcinoma of the cervix should be further investigated.