Related Experiment Video
Updated: Sep 24, 2026

Preparation of Zinc Oxide Nanoparticles and the Evaluation of their Antibacterial Effects
Published on: September 27, 2024
Zinc eluted from siliconized latex urinary catheters decreases OprD expression, causing carbapenem resistance in
M Carmen Conejo1, Isabel García, Luis Martínez-Martínez
1Department of Microbiology, School of Medicine, University of Seville, Seville, Spain. cconejo@us.es
Abstract:
The activities of carbapenems against Pseudomonas aeruginosa decreased in the presence of siliconized latex urinary catheters (SLUCs). This effect was associated with the loss of OprD. The zinc that eluted from SLUCs is responsible for this phenomenon. We have found that zinc exerts a negative effect on the expression of OprD, the porin responsible for carbapenem entry into P. aeruginosa.
Related Concept Videos
Clinical Significance of Antibiotic Resistance
Mechanism of Antibiotic Resistance in MRSA

