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Development and validation of a high-performance liquid chromatography assay for voriconazole
Gennethel J Pennick1, Martin Clark, Deanna A Sutton
1Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA. pennick@uthscsa.edu
Antimicrobial Agents and Chemotherapy
|June 25, 2003
Abstract:
An analytical method for the determination of voriconazole (UK-109,496; Pfizer) in plasma was developed and validated. The method utilizes solid-phase extraction technology and high-performance liquid chromatography. The lower limit of quantitation is 0.2 microg/ml, and the range of linearity tested was 0.2 to 10 microg/ml.