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Functional genomics guided with MR imaging: mouse tumor model study.

Samira Guccione1, Yi-Shan Yang, Gongyi Shi

  • 1Department of Radiology, Stanford University School of Medicine, 1201 Welch Rd, P260, Stanford, CA 94305-5488, USA.

Radiology
|June 25, 2003
PubMed
Summary
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Magnetic resonance (MR) imaging noninvasively characterizes tumor regions for genomic analysis. This approach identified distinct gene expression patterns, revealing MR imaging

Area of Science:

  • Oncology
  • Genomics
  • Medical Imaging

Background:

  • Understanding tumor heterogeneity is crucial for effective cancer treatment.
  • Gene expression patterns vary within different tumor regions.
  • Noninvasive methods are needed to correlate imaging with genomic data.

Purpose of the Study:

  • To investigate the utility of contrast-enhanced magnetic resonance (MR) imaging for characterizing intratumoral regions.
  • To correlate MR imaging findings with gene expression profiles.
  • To establish a noninvasive method for guiding genomic analysis of tumors.

Main Methods:

  • Utilized a mouse tumor model for experimental analysis.
  • Employed contrast material-enhanced MR imaging to differentiate tumor regions.

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  • Performed functional genomics to analyze gene expression profiles from enhanced and nonenhanced areas.
  • Analyzed approximately 11,000 genes for differential expression.

    • Main Results:

    • Identified 10 genes up-regulated in contrast-enhanced regions.
    • Found one gene up-regulated in nonenhanced regions.
    • Several up-regulated genes encode extracellular matrix proteins.
    • Demonstrated high spatial and temporal resolution in characterizing tumor regions.

    Conclusions:

    • Contrast-enhanced MR imaging is a powerful noninvasive tool for tumor characterization.
    • MR imaging can effectively guide genomic analysis by identifying distinct intratumoral regions.
    • This technique provides a valuable correlate between imaging and functional genomics.