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Antimycobacterial activity of 1-substituted indolizines
Lise-Lotte Gundersen1, Ayele H Negussie, Frode Rise
1Department of Chemistry, University of Oslo, Blindern, Norway. l.l.gundersen@kjemi.uio.no
Archiv Der Pharmazie
|June 25, 2003
Abstract:
Indolizine derivatives were tested as antimycobacterials against Mycobacterium tuberculosis H(37)Rv (ATCC 27294)in BACTEC 12B medium using the Microplate Alamar Blue Assay. The most active compounds examined carry an alpha-hydroxybenzyl substituent in the indolizine 1-position. MICs against Mycobacterium tuberculosis for these compounds were 6.25 microg/mL