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IVIG--mechanisms of action
1Department of Pharmacology, University of Bern, Switzerland; ZLB Bioplasma AG, Bern, Switzerland.
Allergy
|June 26, 2003
Summary
Intravenous immunoglobulin (IVIG) contains immune and natural autoantibodies from thousands of donors. These antibodies offer replacement therapy, passive immunization, and modulate immune responses in autoimmune and inflammatory disorders.
Area of Science:
- Immunology
- Pharmacology
Background:
- Intravenous immunoglobulin (IVIG) is derived from pooled plasma of numerous donors.
- IVIG contains both immune and natural autoantibodies.
Purpose of the Study:
- To describe the composition and functions of IVIG preparations.
- To elucidate the mechanisms underlying IVIG's immunomodulatory and anti-inflammatory effects.
Main Methods:
- Fractionation of plasma to obtain IVIG.
- Analysis of antibody content (immune and autoantibodies).
- Review of proposed mechanisms of action for immunomodulation.
Main Results:
- Immune antibodies in IVIG reflect donor population's immunity, useful for replacement and passive immunization.
- Natural autoantibodies may correct immune deregulation in recipients.
- Multiple, synergistic mechanisms contribute to IVIG's anti-inflammatory and immunomodulatory properties.
Conclusions:
- IVIG's therapeutic effects in inflammatory and autoimmune diseases stem from its diverse antibody content.
- The combined action of immune and natural antibodies provides broad therapeutic benefits.