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Plexiform schwannoma.

K Terasaki1, Y Mera, H Uchimiya

  • 1Department of Dermatology, Kagoshima University Faculty of Medicine, Kagoshima, Japan. ken0913@m2.kufm.kagoshima-u.ac.jp

Clinical and Experimental Dermatology
|June 26, 2003
PubMed
Summary

A rare plexiform schwannoma, a benign nerve tumor, presented as a slow-growing mass for 40 years. Immunohistochemical review confirmed the benign diagnosis despite initial suspicion of malignancy.

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Area of Science:

  • Oncology
  • Pathology
  • Dermatology

Background:

  • Plexiform schwannomas are rare, benign peripheral nerve sheath tumors.
  • They exhibit a characteristic multinodular and plexiform growth pattern.
  • These tumors can grow slowly over extended periods.

Observation:

  • A 64-year-old woman presented with a slowly growing trunk mass of 40 years duration.
  • Preoperative biopsy revealed high cellularity and nuclear atypia, raising suspicion for malignancy.
  • The tumor's slow growth over decades suggested a benign etiology despite atypical features.

Findings:

  • Post-excision immunohistochemical analysis was crucial for diagnosis.
  • Markers such as S-100 and Ki67 (MIB1) were utilized.
  • The final diagnosis confirmed a benign plexiform schwannoma, not a malignant peripheral nerve sheath tumor.

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Implications:

  • This case highlights the importance of comprehensive immunohistochemical evaluation in diagnosing rare nerve sheath tumors.
  • It underscores the potential for benign tumors to exhibit features mimicking malignancy.
  • Accurate diagnosis is essential for appropriate patient management and prognosis.