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Hepatic DNA methylation in young, middle-aged, and senescent rats: the effect of mitogen-induced cell proliferation
1Department of Biochemistry and Molecular Biology, Faculty of Science, University of Bari, Italy.
Biochemical Medicine and Metabolic Biology
|December 1, 1992
Abstract:
We have investigated the effect of a single dose of the hepatomitogen lead nitrate on the 5-methyldeoxycytidine (5-mdcyd) content and the HpaII, MspI, and HaeIII restriction patterns of hepatic DNA from young, middle-aged, and senescent rats. It was found that (i) the methylation pattern of genomic DNA changed significantly with age and (ii) the methylation patterns were differentially affected by the liver mitogen in the three cell populations here considered.