Related Experiment Video
Updated: Sep 23, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
Published on: March 3, 2021
Transient hypohidrosis induced by topiramate
Piero de Carolis1, Fabiola Magnifico, Giulia Pierangeli
1Department of Neurological Sciences, University of Bologna, Bologna, Italy.
Purpose:
Hypohidrosis during topiramate (TPM) treatment was recently reported in children. We describe an adult epilepsy patient who developed inability to sweat as well as heat intolerance while undergoing treatment with TPM.
Methods:
To detect the site of the sweat block, patient underwent examination of sweat gland function, cardiovascular autonomic test, and body temperature rhythm determination.
Results:
During TPM treatment, cardiovascular autonomic function and circadian rhythm of body core temperature were normal, whereas thermoregulatory sweat test (TST) showed anhydrosis. This adverse drug effect was quickly resolved after drug discontinuation.
Conclusions:
Because of normal cardiovascular autonomic function and central and peripheral thermoregulatory mechanisms, we hypothesize that hypohidrosis during TPM treatment could be due to a carbonic anhydrases (CA) block at the level of sweat gland.
Related Concept Videos
Transient Ischemic Attack l: Introduction
Thermosensation
Hyperosmolar Hyperglycemic State
Graves Disease II: Pathophysiology
Toxidromes: Clinical Features
Hypoglycemia
