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Transient hypohidrosis induced by topiramate.
Piero de Carolis1, Fabiola Magnifico, Giulia Pierangeli
1Department of Neurological Sciences, University of Bologna, Bologna, Italy.
Epilepsia
|June 26, 2003
Summary
Topiramate (TPM) can cause hypohidrosis (inability to sweat) and heat intolerance in adults, similar to findings in children. This side effect, potentially due to carbonic anhydrase inhibition in sweat glands, resolves after discontinuing TPM.
Area of Science:
- Neurology
- Pharmacology
- Dermatology
Background:
- Topiramate (TPM) is an anticonvulsant medication used for epilepsy and migraine prevention.
- Hypohidrosis, or reduced sweating, has been reported as a rare side effect of TPM, primarily in pediatric populations.
Observation:
- This case study describes an adult patient experiencing hypohidrosis and heat intolerance during TPM treatment.
- The patient presented with a complete inability to sweat (anhydrosis) despite normal cardiovascular autonomic function and body temperature regulation.
Findings:
- A thermoregulatory sweat test (TST) confirmed anhydrosis during TPM therapy.
- The adverse effect of hypohidrosis resolved rapidly upon cessation of TPM treatment.
- Cardiovascular autonomic function and circadian body temperature rhythms remained unaffected.
Implications:
- The findings suggest TPM-induced hypohidrosis in adults may stem from a direct effect on sweat glands, possibly via carbonic anhydrase (CA) inhibition.
- This highlights the importance of monitoring for hypohidrosis and heat intolerance in adult patients on TPM.
- Further research into the mechanism of TPM-induced hypohidrosis is warranted.