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Hormones and the aging process.

John E Morley1

  • 1Division of Geriatric Medicine, Saint Louis University School of Medicine and Geriatrics Research, Education and Clinical Care Center, VA Medical Center, St. Louis, Missouri 63104, USA. morley@slu.edu

Journal of the American Geriatrics Society
|June 26, 2003
PubMed
Summary
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Hormone replacement therapy is largely a myth for slowing aging, with limited evidence supporting its use outside of specific endocrine diseases. Vitamin D and estrogen show promise in preventing hip fractures.

Area of Science:

  • Endocrinology
  • Gerontology
  • Metabolism

Background:

  • Theories linking ductless gland secretions to aging have existed for over a century.
  • Hormone replacement has been proposed as an anti-aging strategy.

Purpose of the Study:

  • To evaluate the scientific evidence supporting hormone replacement therapy for aging.
  • To identify specific conditions where hormone replacement is beneficial.

Main Methods:

  • Review of existing scientific literature and research findings.
  • Analysis of evidence for hormonal influence on the aging process.

Main Results:

  • The concept of a "hormonal fountain of youth" is largely unsupported by modern research.

Related Experiment Videos

  • Strongest evidence supports vitamin D and estrogen replacement for hip fracture prevention.
  • Limited support for hormone replacement in individuals with diagnosed endocrine diseases.

    • Conclusions:

    • Hormone replacement therapy is not a proven method for slowing the general aging process.
    • Clinical application of hormone replacement should be restricted to specific endocrine disorders and fracture prevention.