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A four component coupling strategy for the synthesis of D-phenylglycinamide-derived non-covalent factor Xa inhibitors
Scott M Sheehan1, John J Masters, Michael R Wiley
1Lilly Research Laboratories, A Division of Eli Lilly and Company, IN 46285, Indianapolis, USA. sheehan_scott@lilly.com
Bioorganic & Medicinal Chemistry Letters
|June 26, 2003
Abstract:
A novel isonitrile derivative was synthesized and used in an Ugi four component coupling reaction to explore aryl group substitution effects on inhibition of the coagulation cascade serine protease factor Xa.