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Synthesis and antibacterial activity of oxazolidinone containing sulphonyl group
Yingjie Cui1, Yushe Yang, Kaixian Chen
1Shanghai Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences, 200031, Shanghai, China.
Bioorganic & Medicinal Chemistry Letters
|June 26, 2003
Abstract:
A series of oxazolidinone derivatives carrying sulphonyl group was synthesized and their antibacterial activity was evaluated in vitro. Many of such compounds demonstrated potent antibacterial activity. The activity of a novel compound (YC-20) was 2-4-fold more potent than that of linezolid.