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Synthesis and antimicrobial activity of novel globomycin analogues
Toshihiro Kiho1, Mizuka Nakayama, Kayo Yasuda
1Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd., 140-8710, Tokyo, Japan.
Bioorganic & Medicinal Chemistry Letters
|June 26, 2003
Abstract:
Globomycin, a signal peptidase II inhibitor, and its derivatives show potent antibacterial activity against Gram-negative bacteria. The synthesis and antimicrobial activity of novel globomycin analogues are reported. One of the analogues showed a more potent activity against Gram-negative bacteria than globomycin and also exhibited antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).