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Synthesis of probes with broad pH range fluorescence
Maciej Adamczyk1, Jonathan Grote
1Department of Chemistry (D9MD), Abbott Diagnostics Division, Abbott Laboratories, 100 Abbott Park Road, 60064-6016, Abbott Park, IL, USA. maciej.adamczyk@abbott.com
Bioorganic & Medicinal Chemistry Letters
|June 26, 2003
Abstract:
Reaction of a rhodamine 2'-ester with an excess of alkyldiamines provides amino-functionalized rhodamine spirolactams, which when subsequently conjugated with carboxyfluorescein, provides probes which are fluorescent at acidic, neutral, and basic pH ranges.