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Synthesis and structure-activity relationships of open D-Ring galanthamine analogues
Denyse Herlem1, Marie Thérèse Martin, Claude Thal
1Institut de Chimie des Substances Naturelles, C.N.R.S., 91198 Cedex, Gif-sur-Yvette, France.,
Bioorganic & Medicinal Chemistry Letters
|June 26, 2003
Abstract:
Open D-ring galanthamine analogues were prepared using ring-opening reactions of the quaternarized urethane or oxazolidine functions and were evaluated for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition potency.