Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serpins: structure, function and molecular evolution.

Diana van Gent1, Paul Sharp, Kevin Morgan

  • 1Division of Clinical Chemistry, Institute of Genetics, Queen's Medical Centre, University of Nottingham, NG7 2UH Nottingham, UK.

The International Journal of Biochemistry & Cell Biology
|June 26, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Insomnia disorder and occupational demand in commercial freight driving: A qualitative analysis of symptoms and attributions.

Behavioral sleep medicine·2026
Same author

Data or Deception: Imposter Participants in Online Qualitative Research.

Qualitative health research·2026
Same author

Participant perceptions of HAT TRICK™ Cricket: a culturally-adapted intervention for men with South Asian backgrounds in Australia.

Health promotion international·2026
Same author

A survey of Canadian men's mental health in the workplace.

Cogent mental health·2025
Same author

The Gendered Barriers to Men's Mental Health Peer Support: A Photovoice Study.

Qualitative health research·2025
Same author

Romantic relationship challenges and young men's mental health in Canadian-based undergraduate university students.

Journal of American college health : J of ACH·2025
Same journal

Corrigendum to "Sodium butyrate down-regulation of indoleamine 2, 3-dioxygenase at the transcriptional and post-transcriptional levels" [Int. J. Biochem. Cell Biol. 42 (2010) 1840-1846].

The international journal of biochemistry & cell biology·2026
Same journal

Whole-brain spatial metabolomics reveals metabolic gradient shifts in a murine glioma model following boron neutron capture therapy (130 characters).

The international journal of biochemistry & cell biology·2026
Same journal

LCN2 modulates Th17/Treg balance in vitro and is associated with an adaptive response to intestinal ischemia-reperfusion injury under Hmox1-deficient conditions.

The international journal of biochemistry & cell biology·2026
Same journal

Chloroquine modulates the redox-sensitive signalling via inhibiting the AMPK-ULK1 under LPS induced state in murine splenic macrophages.

The international journal of biochemistry & cell biology·2026
Same journal

The vicious cycle of hyperglycemia and oxidative stress: Novel mechanistic insights into a pathogenic alliance.

The international journal of biochemistry & cell biology·2026
Same journal

Fibroblast growth factors (FGF) in the pathogenesis and treatment of inflammatory bowel diseases (IBD): An overview.

The international journal of biochemistry & cell biology·2026
See all related articles

Serine proteinase inhibitors (serpins) regulate key biological processes. This study reveals that serpin function is determined by protein structure, not just sequence similarity, updating phylogenetic analysis.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Serine proteinase inhibitors (serpins) are crucial for biological processes like blood coagulation, inflammation, and tumor suppression.
  • Serpins exhibit cell-specific expression, with average sizes of 350-400 amino acids, but possess variable gene structures.
  • Previous research classified known serpins into 16 clades and 10 orphan sequences, with vertebrate serpins grouped into six sub-groups.

Purpose of the Study:

  • To update the phylogenetic analysis of serpins.
  • To investigate the relationship between structural and functional properties of serpins.
  • To determine the basis for functional classification within the serpin superfamily.

Main Methods:

  • Phylogenetic analysis incorporating updated data.

Related Experiment Videos

  • Comparative analysis of protein structure and function.
  • Examination of gene structure variations.

    • Main Results:

    • The study provides updated data for phylogenetic analysis of serpins.
    • Structural and functional properties were analyzed in the context of phylogenetic relationships.
    • A key finding is that functional classification depends on protein structure.

    Conclusions:

    • The functional classification of serpins is primarily dictated by their protein structure.
    • Sequence similarity alone is insufficient for accurate functional classification of serpins.
    • This research refines our understanding of serpin superfamily organization and function.