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NRSAS: Nuclear Receptor Structure Analysis Servers.

Emmanuel Bettler1, Roland Krause, Florence Horn

  • 1CMBI KUN, PO Box 9010, 6500 GL Nijmegen, The Netherlands.

Nucleic Acids Research
|June 26, 2003
PubMed
Summary
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We developed Nuclear Receptor Structure Analysis Servers (NRSAS) for comprehensive analysis of nuclear hormone receptors. These freely accessible servers offer tools for homology modeling, structure validation, and 3D visualization.

Area of Science:

  • Biochemistry
  • Structural Biology
  • Bioinformatics

Background:

  • Nuclear hormone receptors play crucial roles in various biological processes.
  • Understanding the structure and function of these receptors is vital for drug discovery and disease research.
  • Existing computational tools for nuclear hormone receptor analysis are fragmented.

Purpose of the Study:

  • To present a suite of integrated computational servers for detailed structure analysis of nuclear hormone receptors.
  • To introduce the NucleaRDB project as a comprehensive information system for these receptors.
  • To provide freely accessible tools for researchers worldwide.

Main Methods:

  • Development of a coherent series of servers for structure analysis.
  • Implementation of homology modeling, structure validation, and contact calculation algorithms.

Related Experiment Videos

  • Integration of accessibility value computation, hydrogen bonding pattern analysis, and mutation prediction.
  • Inclusion of extensive 2D and 3D visualization capabilities.

    • Main Results:

    • The Nuclear Receptor Structure Analysis Servers (NRSAS) offer a wide range of analyses.
    • These servers facilitate in-depth investigation of nuclear hormone receptor structures.
    • The NucleaRDB project provides a unified information system for these receptors.

    Conclusions:

    • NRSAS provides a powerful and accessible platform for nuclear hormone receptor structure analysis.
    • The NucleaRDB project enhances research accessibility and data integration for nuclear hormone receptors.
    • These freely available servers will advance the study of nuclear hormone receptor function and dysfunction.