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Mfold web server for nucleic acid folding and hybridization prediction.
1Department of Mathematical Sciences, Rensselaer Polytechnic Institute, Troy, NY 12180, USA. zukerm@rpi.edu
Nucleic Acids Research
|June 26, 2003
Summary
The mfold web server provides accessible RNA and DNA secondary structure prediction software. It offers detailed outputs for single sequences and bulk analysis for hundreds of sequences, simplifying nucleic acid folding research.
Area of Science:
- Bioinformatics
- Computational Biology
- Molecular Biology
Background:
- Predicting nucleic acid secondary structure is crucial for understanding molecular function.
- Existing software often presents portability challenges for researchers.
Purpose of the Study:
- To provide the scientific community with easy access to RNA and DNA folding and hybridization software.
- To overcome software portability issues using web-based graphical user interfaces.
Main Methods:
- Development of the mfold web server, a collection of related WWW applications.
- Utilization of web GUIs for universal accessibility.
- Implementation of detailed output options including structure plots, reliability information, and energy dot plots.
Main Results:
- The mfold web server offers user-friendly access to nucleic acid folding software.
- Detailed outputs are available for single sequence analysis.
- Bulk servers provide rapid analysis for numerous sequences.
Conclusions:
- The mfold web server effectively democratizes access to essential bioinformatics tools.
- It facilitates research in RNA and DNA structure prediction and hybridization.