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Related Experiment Videos

Signal search analysis server.

Giovanna Ambrosini1, Viviane Praz, Vidhya Jagannathan

  • 1ISREC Swiss Institute for Experimental Cancer Research, Ch. des Boveresses 155, 1066 Epalinges s/ Lausanne, VD, Switzerland.

Nucleic Acids Research
|June 26, 2003
PubMed
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Signal search analysis identifies sequence motifs near functional sites, aiding in understanding gene regulation. This method is crucial for analyzing eukaryotic promoter elements and evolutionary constraints.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • Signal search analysis is a key method for identifying sequence motifs correlated with functional sites.
  • It has been instrumental in analyzing eukaryotic promoter elements, contributing to our understanding of gene regulation.

Purpose of the Study:

  • To provide access to computational tools for signal search analysis.
  • To enable the discovery and characterization of sequence motifs related to functional sites.

Main Methods:

  • Utilizes four distinct computer programs for motif discovery and analysis.
  • Offers precompiled functional site collections for comprehensive analysis.
  • Includes methods for identifying evolutionary constraints, detecting over/under-represented motifs, and analyzing positional distributions.

Related Experiment Videos

Main Results:

  • Enables identification of non-random sequence regions under evolutionary constraint.
  • Facilitates detection of consensus sequence motifs at specific distances from functional sites.
  • Allows optimization of weight matrix descriptions for sequence motifs.

Conclusions:

  • The signal search analysis server provides a valuable resource for motif discovery.
  • The available programs enhance the characterization of sequence motifs and their functional relevance.
  • This approach is essential for advancing research in eukaryotic gene regulation and genomics.