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Related Concept Videos

Globular and Fibrous Proteins02:21

Globular and Fibrous Proteins

Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities.
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...
Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Globular and Fibrous Proteins02:21

Globular and Fibrous Proteins

Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities.
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...
Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
Globular Proteins01:27

Globular Proteins

In organisms, proteins are the most abundant macromolecules. They act as the building blocks of life and play various crucial roles in the body. Proteins can be broadly classified into two distinct subtypes based on their shape and solubilities: globular proteins and fibrous proteins.
Globular proteins serve many important physiological functions, such as acting as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be soluble in the aqueous...

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Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
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GlobPlot: Exploring protein sequences for globularity and disorder.

Rune Linding1, Robert B Russell, Victor Neduva

  • 1European Molecular Biology Laboratory, Biocomputing Unit, D-69117 Heidelberg, Germany. linding@embl.de

Nucleic Acids Research
|June 26, 2003
PubMed
Summary
This summary is machine-generated.

GlobPlot is a new web tool that predicts protein disorder and order. It helps identify unstructured regions and linear motifs important for protein function and structural biology.

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Last Updated: Jun 6, 2026

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

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Published on: July 14, 2015

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09:51

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Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing
12:04

Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing

Published on: October 3, 2018

Area of Science:

  • Proteomics
  • Structural Genomics
  • Bioinformatics

Background:

  • Predicting protein structure and function, especially disordered regions, is a key challenge.
  • Short linear motifs in unstructured protein segments are crucial for biological function.

Purpose of the Study:

  • To introduce GlobPlot, a web service for identifying disordered protein regions.
  • To aid in domain hunting and designing protein constructs for structural studies.

Main Methods:

  • Development of the GlobPlot web service for plotting protein order/disorder propensity.
  • Utilizing GlobPlot for analysis of known proteins to identify functional regions.
  • Introduction of GlobPipe for large-scale proteome analysis.

Main Results:

  • GlobPlot successfully identifies inter-domain segments with linear motifs.
  • The tool highlights ordered regions lacking known domains and ordered terminal segments of known domains.
  • Demonstrated utility in domain hunting and construct design for structural biology.

Conclusions:

  • GlobPlot is a valuable tool for predicting protein disorder and identifying functional regions.
  • It assists in understanding protein structure, function, and in experimental design for structural biology.
  • GlobPlot and GlobPipe enable comprehensive proteome-wide disorder analysis.