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Neurobrucellosis.

P G Samdani1, Shalaaka Patil

  • 1Department of Pediatrics, Bhatia General Hospital, Tardeo, Mumbai 400 007, India. drsamdanipg@hotmail.com

Indian Pediatrics
|June 26, 2003
PubMed
Summary
This summary is machine-generated.

A pediatric case of Brucellosis presented with high-grade fever and focal convulsions. Prompt diagnosis and combination antibiotic therapy led to a favorable outcome, highlighting effective treatment for neurobrucellosis.

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Area of Science:

  • Pediatric Neurology
  • Infectious Diseases
  • Neuroscience

Background:

  • Brucellosis is a zoonotic bacterial infection that can affect multiple organ systems.
  • Neurological involvement in Brucellosis (neurobrucellosis) is rare but can lead to severe complications.
  • Early recognition and appropriate management are crucial for favorable outcomes.

Observation:

  • A six-year-old female presented with high-grade fever and focal convulsions.
  • Initial systemic examination was unremarkable.
  • Repeated Widal tests were positive, and MRI of the brain revealed bilateral cerebritis.

Findings:

  • Blood antibody titers against Brucella were positive, confirming the diagnosis.
  • The patient received a 6-month course of combination antibiotic therapy.

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  • Initial treatment included doxycycline, rifampicin, and gentamicin, with gentamicin later replaced by streptomycin.

    • Implications:

    • This case underscores the importance of considering Brucellosis in the differential diagnosis of febrile seizures and cerebritis in children.
    • Effective management of neurobrucellosis requires a tailored antibiotic regimen.
    • Successful treatment can prevent long-term neurological sequelae.