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Heat stability of the lyophilized Sabin poliovaccine
Hiroshi Shiomi1, Tomoko Urasawa, Shozo Urasawa
1Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan. urasawa@fujijoshi.ac.jp
Japanese Journal of Infectious Diseases
|June 26, 2003
Abstract:
In this study we lyophilized three types of live attenuated polioviruses (Sabin vaccine strains) and evaluated the lyophilized vaccine viruses' heat stability. The virus titers were measured after heating at 37 and 45 and then compared with the titers of conventional liquid vaccine viruses similarly treated. The results showed that lyophilization, while slightly reducing vaccine virus titers, had a far greater sparing effect on subsequent heat inactivation of lyophilized vaccine viruses, thus demonstrating its validity for the improvement of the vaccine.