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Industrial experience with the detection of retroviruses
A M Losikoff1, J A Poiley, R Raineri
1Biotechnology Services Laboratory, Hazleton Washington, Inc., Kensington, MD 20895.
Developments in Biological Standardization
|January 1, 1992
Abstract:
An important aspect of the virological assessment of cell substrates used to produce biologicals is their retroviral status. In this presentation we will attempt to document some of the practical experiences of industry when testing cell substrates for retroviruses using infectivity tests, reverse transcriptase and electron microscopy. We will also explore some important aspects of the experimental design of these retrovirus assay systems and review some results from the application of these methods in model, experimental systems.