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Lactate levels in children with HIV/AIDS on highly active antiretroviral therapy

Ninad Desai1, Mudit Mathur, Jeremy Weedon

  • 1Children's Hospital, SUNY Downstate Medical Center, Brooklyn Pediatric AIDS Network, Brooklyn, NY, USA.

AIDS (London, England)
|June 26, 2003
PubMed

Insights

Elevated lactate levels in children with HIV/AIDS may indicate adherence to antiretroviral therapy. Asymptomatic hyperlactatemia was common and not linked to severe liver issues.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Pharmacology

Background:

  • Human Immunodeficiency Virus (HIV) infection impacts children globally.
  • Antiretroviral therapy (ART) is crucial for managing pediatric HIV/AIDS.
  • Lactate metabolism can be affected by various medical conditions and treatments.

Purpose of the Study:

  • To investigate venous lactate levels in children with HIV/AIDS.
  • To determine the prevalence of hyperlactatemia in this population.
  • To explore the association between lactate levels, ART, and viral load.

Main Methods:

  • Collected 251 venous lactate measurements from 127 children with HIV/AIDS.
  • Classified children based on ART status (on therapy vs. not on therapy).
  • Analyzed lactate levels in relation to treatment regimens and viral load.

Main Results:

  • 41 children (32.3%) exhibited asymptomatic hyperlactatemia (> 2 mmol/l).
  • No cases of hepatic dysfunction or life-threatening lactic acidosis were observed.
  • Asymptomatic hyperlactatemia correlated with the use of nucleoside reverse transcriptase inhibitors (NRTIs) or protease inhibitors (PIs) and undetectable viral loads.

Conclusions:

  • Asymptomatic hyperlactatemia is a notable finding in children with HIV/AIDS on ART.
  • Elevated lactate levels appear to be associated with adherence to specific ART components.
  • Venous lactate measurements may serve as a potential biomarker for evaluating treatment adherence in pediatric HIV/AIDS.

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