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The conformational specificity of viral epitopes
1Institut de Biologie Moléculaire et Cellulaire, CNRS, Strasbourg, France.
FEMS Microbiology Letters
|December 15, 1992
Abstract:
Four types of antigenic sites found in viruses are discussed: cryptotopes, neotopes, metatopes and neutralization epitopes. The role played by conformation on the specificity of viral epitopes is illustrated in the case of tobacco mosaic virus and influenza virus. It appears that mechanisms reminiscent of induced fit contribute to the recognition of viral epitopes by antibodies.