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Evaluating dose regimens of apomorphine, an open-label study
A Kongkanand1, J Opanuraks, K Tantiwongse
1Division of Urology, Department of Surgery, Chulalongkorn University Hospital, Bangkok, Thailand. apichat.k@chula.ac.th
International Journal of Impotence Research
|June 26, 2003
Summary
Apomorphine sublingual (apo SL) is a safe and effective treatment for erectile dysfunction (ED) in Asian men. The study found significant improvements in erectile function and sexual satisfaction after 10 weeks of treatment.
Area of Science:
- Urology
- Pharmacology
- Men's Health
Background:
- Erectile dysfunction (ED) is a common condition affecting men's sexual health.
- Apomorphine sublingual (apo SL) is an emerging treatment option for ED.
Purpose of the Study:
- To evaluate the safety and efficacy of apomorphine sublingual (apo SL) at 2 and 3 mg doses.
- To assess treatment outcomes in Asian men with erectile dysfunction using a dose-optimization regimen.
Main Methods:
- A 10-week, open-label study involving 110 Asian men with ED.
- Dose optimization of apomorphine sublingual (apo SL) at 2 and 3 mg.
- Data collection through daily patient diaries and the International Index for Erectile Function (IIEF) questionnaire.
Main Results:
- 63% of participants reported improvements in sexual life.
- Significant improvements observed in erectile function (IIEF score from 15.9 to 20.4).
- Improvements noted in intercourse satisfaction (7.7 to 9.9), orgasmic function (6.8 to 7.5), and total satisfaction (41.9 to 50.8).
Conclusions:
- Apomorphine sublingual (apo SL) is safe and efficacious for treating ED in this Asian male population.
- Treatment benefits were observed irrespective of underlying diseases or concomitant medications.
- Further research may explore its impact on sexual desire.