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Updated: Sep 23, 2026
Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
Published on: August 17, 2022
[Value of the intraoperative determination of parathyroid hormone (PTH) in hyperparathyroidism surgery]
M J Ferrer Ramírez1, A López Gutierrez, M J Oliver Oliver
1Servicio de Otorrinolaringología, Hospital Universitario Dr. Peset, Valencia. mferrero@seorl.org
Introduction:
The success in the surgical management of hyperparathyroidism has conventionally required a bilateral neck exploration. The intraoperative monitoring of intact parathyroid hormone (PTHi), allows a less extensive procedure by confirming the complete removal of hypersecreting tissue.
Methods:
Plasma samples were obtained from 32 consecutive patients before and 10 minutes after removal of abnormal parathyroid tissue. PTH was measured with a modifie immunochemiluminometric assay with a short incubation time and the results made available in 15 minutes.
Results:
PTHi decreased by at least 60% in 30 of 32 cases. A single adenoma was removed in 26 cases, and multiple hyperplastic glands in 4 cases. The two cases in which PTHi fell < 60% were diagnosed as hyperplasia. PTHi decreased > 60% after the removal of the remnant hyperplastic glands.
Conclusions:
The rapid PTHi assay had excellent analytical performance and predicted the success of parathyroid surgery.
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