[Duo-Bonharen--a new viscoelastic preparation. Experimental study]

Area of Science:

• Ophthalmology
• Biomaterials Science
• Surgical Innovation

Context:

• Ophthalmosurgery requires advanced viscoelastic preparations for tissue protection and surgical manipulation.
• Current viscomaterials have limitations that necessitate the development of improved alternatives.
• Hyaluronic acid-based preparations are increasingly utilized in eye surgery due to their biocompatibility.

Purpose:

• To evaluate the preclinical safety and efficacy of Duo-Bonharen, a novel viscoelastic preparation for ophthalmic surgery.
• To assess the intraocular pressure effects and tissue interaction of Duo-Bonharen.
• To compare the performance of Duo-Bonharen with existing viscomaterials used in eye procedures.

Summary:

• Duo-Bonharen, a viscoelastic preparation utilizing bacterially fermented hyaluronic acid, demonstrated no adverse effects on intraocular pressure or ocular tissues in preclinical testing.
• The 5% dispersed form exhibits excellent adherence to ocular tissues, providing adequate protection during surgery.
• The 1.5% cohesive form is easily removable from the anterior chamber post-procedure.
• Experimental results indicate Duo-Bonharen's properties are comparable to established viscomaterials.

Impact:

• Duo-Bonharen shows promise as a safe and effective viscoelastic agent for ophthalmic surgeries, particularly cataract surgery.
• Successful clinical trials could lead to the adoption of Duo-Bonharen, potentially improving surgical outcomes and patient safety.
• This research contributes to the field of ophthalmic biomaterials, offering a new option for surgeons.