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Published on: November 20, 2015
The HELLP-syndrome; maternal-fetal outcome and follow up of infants
Anne C Roelofsen1, Maria G van Pampus, Jan G Aarnoudse
1Department of Obstetrics and Gynecology, Division of Obstetrics and Perinatal Medicine, University Hospital Groningen, Groningen, The Netherlands.
Objective:
To investigate maternal-fetal outcome of infants born after pregnancies complicated by (H)ELLP syndrome.
Study Design:
A retrospective cohort study was performed on patients with the HELLP or ELLP syndrome. Maternal and perinatal complications were recorded. The follow-up period of the infants was at least 18 months. A multivariate regression analysis was done to define the variables mostly contributing to adverse outcome.
Results:
No maternal deaths occurred. Eighteen infants of the HELLP group and six infants of the ELLP group died; total perinatal mortality was 17.6%. After 18 months four infants had major handicaps, making a total adverse outcome of 22.8%. Statistical analysis shows early gestational age, prolongation of pregnancy and administration of antihypertensive medication as the factors influencing outcome of the infants most.
Conclusions:
Prolongation of pregnancy contributed to better perinatal outcome, while administration of antihypertensive medication and early gestational age were related to a more unfavorable outcome.
