Related Experiment Video
Updated: Sep 23, 2026

Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation
Published on: February 29, 2020
The abnormal fontanel
1Department of Family Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45239, USA. kieslehj@fammed.uc.edu
Insights
Understanding normal fontanel variation is key for diagnosing infants. Abnormalities like large or bulging anterior fontanels can indicate serious conditions such as increased intracranial pressure or developmental disorders.
Area of Science:
- Pediatrics
- Neonatology
- Developmental Biology
Background:
- Infants are born with six fontanels, crucial anatomical landmarks for clinical assessment.
- The anterior fontanel, the largest, typically measures 2.1 cm and closes around 13.8 months.
- Variations in fontanel size and closure time are common and require careful evaluation.
Purpose of the Study:
- To review the diagnostic criteria for abnormal fontanel presentation in infants.
- To outline common causes associated with large or delayed fontanel closure.
- To describe the significance of bulging or sunken fontanels in clinical practice.
Main Methods:
- Review of existing literature on infant fontanels and their clinical significance.
- Analysis of common etiological factors for abnormal fontanel findings.
- Correlation of physical examination findings with diagnostic imaging modalities.
Main Results:
- Delayed closure or large anterior fontanels are linked to achondroplasia, hypothyroidism, Down syndrome, increased intracranial pressure, and rickets.
- Bulging fontanels may indicate increased intracranial pressure or tumors; sunken fontanels suggest dehydration.
- Physical examination guides the selection of appropriate imaging techniques for diagnosis.
Conclusions:
- Accurate diagnosis of abnormal fontanels relies on understanding normal developmental variations.
- Prompt identification of fontanel abnormalities is essential for timely intervention and management.
- Clinical assessment combined with imaging plays a vital role in diagnosing underlying pediatric conditions.
Abstract:
The diagnosis of an abnormal fontanel requires an understanding of the wide variation of normal. At birth, an infant has six fontanels. The anterior fontanel is the largest and most important for clinical evaluation. The average size of the anterior fontanel is 2.1 cm, and the median time of closure is 13.8 months. The most common causes of a large anterior fontanel or delayed fontanel closure are achondroplasia, hypothyroidism, Down syndrome, increased intracranial pressure, and rickets. A bulging anterior fontanel can be a result of increased intracranial pressure or intracranial and extracranial tumors, and a sunken fontanel usually is a sign of dehydration. A physical examination helps the physician determine which imaging modality, such as plain films, ultrasonography, computed tomographic scan, or magnetic resonance imaging, to use for diagnosis.
Related Concept Videos
Anatomy of the Brain: Ventricles
Neurulation
Cranial Bones: Superior and Posterior View
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...
Brain Abscess l: Introduction
Cardiovascular System Abnormal Findings II: Auscultation
Abnormal Heart Sounds
Gallops:
Aneurysm I: Introduction

