Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Current concepts in diabetic gastroparesis.

D Scott Smith1, Christopher D Ferris

  • 1Department of Medicine, Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.

Drugs
|June 27, 2003
PubMed
Summary

Diabetic gastroparesis, a common diabetes complication, causes delayed gastric emptying due to enteric nervous system defects. Current treatments are limited, prompting research into novel therapies like nitric oxide signaling augmentation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Studies with model compounds indicate that key chemical moieties of dissolved organic carbon (DOC) influence transepithelial potential in rainbow trout at circumneutral and low pH.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP·2026
Same author

The Utility of Fish Population Monitoring and Forecast Trigger Development for Designing Adaptive Aquatic Monitoring Plans for Large Industrial Developments.

Environmental management·2025
Same author

Dissolved organic carbon from "white" waters in Amazon basin (Brazil) and the osmoregulatory responses of tambaqui (Colossoma macropomum) in neutral and acidic environments.

Journal of fish biology·2025
Same author

Impact of organic matter constituents on phosphorus recovery from CPR sludges.

Water environment research : a research publication of the Water Environment Federation·2024
Same author

Using physicochemical properties to predict the impact of natural dissolved organic carbon on transepithelial potential in the freshwater rainbow trout (Oncorhynchus mykiss) at neutral and acidic pH.

Fish physiology and biochemistry·2024
Same author

Natural organic matter (NOM) can increase the uptake fluxes of three critical metals (Ga, La, Pt) in a unicellular green alga.

Chemosphere·2024

Area of Science:

  • Gastroenterology
  • Endocrinology
  • Diabetology

Background:

  • Diabetic gastroparesis is a prevalent and severe complication of diabetes mellitus, impacting millions globally.
  • Despite being recognized for over 50 years, effective treatment options for diabetic gastroparesis remain scarce.
  • The precise etiology of gastric dysfunction in diabetic patients has only recently begun to be elucidated.

Purpose of the Study:

  • To review the current understanding of diabetic gastroparesis, including its pathophysiology, diagnosis, and treatment limitations.
  • To highlight emerging research into the molecular mechanisms underlying diabetic gastroparesis.
  • To discuss potential novel therapeutic strategies targeting these mechanisms.

Main Methods:

  • Review of existing scientific literature on diabetic gastroparesis.
  • Analysis of diagnostic criteria and current treatment modalities.
  • Exploration of recent animal studies investigating the molecular pathophysiology.

Main Results:

  • Diabetic gastroparesis affects up to 50% of diabetes patients, causing symptoms like nausea and vomiting.
  • Diagnosis involves symptom assessment and exclusion of other conditions, confirmed by gastric emptying studies.
  • Current treatments include dietary changes, limited medications (metoclopramide, erythromycin, domperidone), and surgical interventions, with limited efficacy and side effects.

Conclusions:

  • The molecular pathophysiology of diabetic gastroparesis is largely unknown, hindering rational therapy development.
  • Emerging research suggests a defect in the enteric nervous system, specifically impaired nitric oxide signaling, is a key cause.
  • Novel therapies aimed at enhancing nitric oxide signaling show promise for future treatment of this condition.

Related Experiment Videos