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Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
Are current strategies for treating hypertension effective?
1Section of Clinical Pharmacology and Hypertension, Division of Nephrology, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298-0160, USA. dsica@hsc.vcu.edu
Insights
Effective hypertension management aims to prevent organ damage and reduce cardiovascular and renal risks. Optimal treatment requires early, intensive, and persistent intervention, alongside lifestyle changes and individualized blood pressure goals.
Area of Science:
- Cardiology
- Nephrology
- Public Health
Background:
- Hypertension management aims to prevent target organ damage and reduce cardiovascular and renal mortality.
- Despite proven benefits of blood pressure reduction, many patients do not receive optimal care.
- Suboptimal treatment is often due to insufficient early, intensive, or persistent management by healthcare providers.
Purpose of the Study:
- To highlight paradigm shifts in hypertension management over the past decade.
- To emphasize the need for comprehensive cardiovascular risk assessment and individualized blood pressure targets.
- To guide primary care providers in optimizing hypertension treatment strategies.
Main Methods:
- Review of clinical trial data and population-based studies on hypertension management.
- Analysis of recent shifts in therapeutic approaches and guidelines.
- Focus on primary care provider awareness and patient-specific risk stratification.
Main Results:
- Key shifts include promoting lifestyle changes, comprehensive risk assessment, individualized blood pressure targets, emphasis on systolic pressure, and increased use of multidrug therapy.
- Multidrug therapy, including fixed-dose combinations, is increasingly used to achieve treatment goals.
- Individualized blood pressure targets based on patient risk profiles are crucial.
Conclusions:
- Primary care providers must enhance awareness of cardiovascular risk factors and early organ damage markers.
- Individualized treatment goals and proactive management are essential for effective hypertension control.
- Optimizing hypertension care reduces cardiovascular and renal morbidity and mortality.
Abstract:
The ultimate goal of hypertension management is to prevent or reverse target organ damage and thereby to reduce cardiovascular and renal morbidity and mortality. Over the past two decades, abundant data from population-based, randomized, controlled trials have demonstrated the clinical benefits of blood pressure reduction for individuals with hypertension. Yet a large majority of patients with high blood pressure fail to receive optimal medical management for their hypertension. It appears that a leading obstacle to achieving blood pressure control in the general population is the failure of health care providers to treat high blood pressure sufficiently early, intensively, and persistently. In the past decade, there have been several paradigm shifts in the management of high blood pressure, including: 1). actively intervening to encourage therapeutic lifestyle changes; 2). conducting more comprehensive cardiovascular risk assessments; 3). achieving and maintaining a target blood pressure that is determined by the individuals level of risk; 4). placing a greater emphasis on lowering systolic blood pressure, particularly in older adults; and 5). increasing the use of multidrug therapy, given either as separate components or in the form of a fixed-dose combination, to achieve blood pressure goals. Primary care providers need to heighten their awareness of factors contributing to cardiovascular risk, recognize the very early markers of target organ damage, and set blood pressure goals that are individualized to a patients unique risk profile.
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