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Related Experiment Videos

Kikuchi-Fujimoto lymphadenitis.

Mihaela Onciu1, L Jeffrey Medeiros

  • 1Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. Mihaela.Onciu@St.Jude.org

Advances in Anatomic Pathology
|June 27, 2003
PubMed
Summary

Kikuchi-Fujimoto disease (KFD), or histiocytic necrotizing lymphadenitis, is a benign condition presenting with diverse clinical and histologic features. This review details KFD

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Area of Science:

  • Pathology
  • Immunology
  • Infectious Disease

Background:

  • Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare, benign lymphadenopathy.
  • Initially described in Southeast Asia, KFD has been reported globally across diverse demographics.
  • Extranodal involvement and varied clinical presentations are recognized features.

Purpose of the Study:

  • To review the clinical, laboratory, histologic, and immunophenotypic characteristics of KFD.
  • To emphasize the differential diagnosis of KFD, particularly with other necrotizing lymphadenitides and lymphomas.
  • To discuss unusual presentations and extranodal manifestations of KFD.

Main Methods:

  • Literature review of KFD cases.
  • Analysis of clinical, laboratory, and histopathologic findings.
  • Comparison with differential diagnoses including lymphoma.

Main Results:

  • KFD exhibits a wide spectrum of clinical and histologic features.
  • The disorder is not limited to specific geographic regions or demographics.
  • Differential diagnosis requires careful consideration of necrotizing lymphadenitis and malignant lymphoma.

Conclusions:

  • KFD likely represents a reactive pattern to various etiologic agents rather than a distinct entity.
  • Comprehensive evaluation is crucial for accurate diagnosis and management.
  • Understanding KFD's diverse presentations aids in distinguishing it from more severe conditions.

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