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Related Experiment Videos

Chronically infused intrathecal morphine in dogs.

Tony L Yaksh1, Kjersti A Horais, Nicolle A Tozier

  • 1Department of Anesthesiology, University of California San Diego, La Jolla 92093, USA. tyaksh@ucsd.edu

Anesthesiology
|June 27, 2003
PubMed
Summary

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High intrathecal morphine concentrations can cause aseptic inflammatory masses and hind limb dysfunction in dogs. Clonidine may reduce these adverse effects, suggesting its potential utility in coadministration for pain management.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Toxicology

Background:

  • Intrathecal morphine infusion is widely used for pain management.
  • Systematic safety studies on high-concentration intrathecal morphine are lacking.
  • This study investigates the safety of prolonged intrathecal morphine and clonidine administration.

Purpose of the Study:

  • To assess the safety and effects of high-concentration intrathecal morphine in dogs.
  • To evaluate the potential neuroprotective effects of co-administered clonidine.

Main Methods:

  • Beagle dogs received 28-day intrathecal infusions via lumbar catheters.
  • Groups received varying doses of morphine (1.5-12 mg/day) or morphine with clonidine.
  • Control groups received saline or clonidine alone.

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Main Results:

  • High-dose morphine (9-12 mg/day) induced allodynia and hind limb dysfunction.
  • Concentration-dependent aseptic inflammatory masses formed at the catheter tip in high-dose morphine groups.
  • Clonidine alone had no adverse effects and reduced morphine-induced reactions when co-administered.

Conclusions:

  • High-concentration intrathecal morphine can cause aseptic inflammatory masses and neurological deficits.
  • Clonidine may mitigate these adverse effects, suggesting its potential therapeutic benefit in combination therapy.
  • Further research is warranted to explore the coadministration of morphine and clonidine for pain management.