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Related Experiment Videos

Rectal manometry in patients with isolated sacral agenesis.

Claudio Morera1, Samuel Nurko

  • 1Gastrointestinal Motility Unit, Combined Program in Gastroenterology and Nutrition, Children's Hospital, Boston, Massachusetts 02115, U.S.A.

Journal of Pediatric Gastroenterology and Nutrition
|June 27, 2003
PubMed
Summary

Children with sacral agenesis experience fecal and urinary incontinence due to altered anorectal function. Rectal manometry reveals impaired rectoanal inhibitory reflex (RAIR) in these patients.

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Area of Science:

  • Pediatric Gastroenterology
  • Neuro-urology
  • Colorectal Surgery

Background:

  • Sacral agenesis is a congenital anomaly affecting the sacral nerves.
  • Sacral nerve abnormalities can impact bowel and bladder control.
  • Anorectal manometry is a key diagnostic tool for evaluating defecation disorders.

Purpose of the Study:

  • To evaluate anorectal manometry findings in children with sacral agenesis.
  • To correlate manometric abnormalities with neurological and continence status.
  • To understand the impact of sacral root abnormalities on rectal function.

Main Methods:

  • Retrospective analysis of anorectal manometry in seven children with isolated sacral agenesis.
  • Comparison of manometric data with healthy controls.

Related Experiment Videos

  • Assessment of internal anal sphincter (IAS) pressure, rectoanal inhibitory reflex (RAIR), squeeze pressure, and rectal sensation.
  • Chart review for urinary and fecal continence.

    • Main Results:

    • All patients with sacral agenesis had fecal and urinary incontinence.
    • IAS resting pressure was similar between patients and controls.
    • Patients with complete sacral agenesis showed prolonged IAS relaxation, reduced voluntary external anal squeeze pressure, and blunted rectal sensation.

    Conclusions:

    • Sacral agenesis is associated with significant anorectal dysfunction.
    • Abnormal parasympathetic innervation impacts the RAIR, contributing to fecal incontinence.
    • Manometric findings highlight the role of extrinsic innervation in modulating rectal function.