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Delayed sodium channel inactivation mimics long QT syndrome 3
Volker Kühlkamp1, Christian Mewis, Ralph Bosch
1Eberhard-Karls-Universität Medizinische Klinik III, Tübingen, Germany. volker.kuehlkamp@med.uni-tuebingen.de
Journal of Cardiovascular Pharmacology
|June 27, 2003
Abstract:
DPI 201-106 delays sodium channel inactivation. Acute administration of DPI 201-106 prolonged the QT interval, provoked spontaneous torsades de pointes in one patient, and facilitated stimulation-induced polymorphic ventricular tachyarrhythmias in two patients. Similar to the observations in animal studies, delaying sodium channel inactivation is a new form of the acquired long QT syndrome, mimicking long QT syndrome type 3.