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Updated: Jul 31, 2026

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
Published on: May 19, 2015
A confirmatory study on the mechanisms behind reduced P300 waves in depression
Joachim Röschke1, Peter Wagner
1Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, 55101 Mainz, Germany. roeschke@mail.uni-mainz.de
Abstract:
A single-trial analysis of event-related potentials (P300) of 21 depressives was performed in comparison with matched controls. The purpose was to confirm previous results revealing an overall reduction of the single-trial P300 amplitude in depression despite fewer elicited single-trial P300 waves in schizophrenics. The result of the present study is in line with our previous investigation implicating a general reduced P300 amplitude on single trials of depressive patients. Therefore, it appears possible to differentiate depressives and schizophrenics by measuring event-related potentials and applying a single-trial analysis of them.
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