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Related Experiment Videos

[Methotrexate-induced skin detachment].

S Aractingi1, E Briant, J P Marolleau

  • 1Clinique des Maladies cutanées, Hôpital Saint-Louis, Paris.

Presse Medicale (Paris, France : 1983)
|October 24, 1992
PubMed
Summary
This summary is machine-generated.

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High-dose methotrexate can cause rare, severe skin erosions and other organ damage. Granulocyte-colony stimulating factor (G-CSF) aided recovery from bone marrow aplasia.

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • High-dose methotrexate is used for high-grade lymphoma.
  • Methotrexate commonly causes integument and mucosal toxicity.
  • Cutaneous lesions of the skin proper are rare complications.

Observation:

  • A male patient developed extensive skin erosions after a 5-gram intravenous dose of methotrexate.
  • The patient also experienced renal, hepatic, and mucosal lesions, along with bone marrow aplasia.
  • The mechanism of cutaneous necrosis is hypothesized to be direct epidermal toxicity from methotrexate.

Findings:

  • The patient was treated with granulocyte-colony stimulating factor (G-CSF).
  • Recovery from bone marrow aplasia occurred within 6 days without infectious complications.

Related Experiment Videos

  • G-CSF may mitigate infection risk by shortening cytopenia duration.

    • Implications:

    • This case highlights a rare but severe dermatological adverse effect of high-dose methotrexate.
    • Early intervention with G-CSF can be crucial for managing methotrexate-induced complications.
    • Understanding methotrexate toxicity mechanisms is vital for patient management in oncology.