[TNF alpha-antagonists in collagen vascular disease]

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A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model
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Published on: October 30, 2019

K Manger1, B Manger

  • 1Institut für klinische Immunologie und Rheumatologie, Med. Klinik III mit Poliklinik, Krankenhausstr. 12, 91054 Erlangen, Germany. karin.manger@med3.imed.uni-erlangen.de

Zeitschrift Fur Rheumatologie
|June 27, 2003
PubMed

Insights

Biologics targeting TNF alpha effectively treat rheumatic diseases. However, their use in collagen vascular diseases is limited due to potential side effects like drug-induced lupus, necessitating a review of existing case reports.

Area of Science:

  • Rheumatology
  • Immunology
  • Pharmacology

Background:

  • Biologics, particularly TNF alpha inhibitors, have revolutionized rheumatic disease therapy.
  • TNF alpha inhibition demonstrates significant efficacy in suppressing systemic inflammation.

Purpose of the Study:

  • To review individual case reports of anti-TNF alpha therapy in collagen vascular diseases.
  • To summarize current knowledge on the efficacy and safety of anti-TNF alpha therapy for this specific indication.

Main Methods:

  • Systematic review of published case reports.
  • Analysis of patient data regarding treatment efficacy and adverse events.

Main Results:

  • Limited clinical studies exist for anti-TNF alpha therapy in collagen vascular diseases.
  • Observed side effects include newly developed antinuclear antibodies and drug-induced lupus.

Conclusions:

  • Anti-TNF alpha therapy shows potential but requires careful evaluation in collagen vascular diseases.
  • Further research is needed to establish definitive efficacy and safety profiles for this patient group.

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