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Interferon-neutralizing or enhancing activities in hybridoma cell fluids after in vitro immunization
D Stancek1, M Stanceková, J K Pimenta
1Institute of Preventive and Clinical Medicine, Commenius University, Bratislava, Czechoslovakia.
Acta Virologica
|August 1, 1992
Abstract:
Several hybridomas supernatants capable of interferon beta (IFN-beta) or "IFN epsilon" ("IFN-eps") neutralizing or enhancing activities were obtained after in vitro immunization of BALB/c and C57 mice spleen cells and their fusion with Sp2/0 plasmacytoma cells. Besides rather low anti-IFN-beta or "eps" antibody secretion several cloned hybridoma fluids contained a factor potentiating anti-viral activity of the both IFNs. It is speculated that this activity is due to production by some hybridomas of another lymphokine.