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Updated: Sep 23, 2026

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
Published on: November 5, 2019
[Hereditary spherocytosis -- prevalence of erythrocyte membrane protein deficiency]
Elisa Granjo1, Pedro Manata, Noémia Torres
1Serviço de Hematologia Clínica, Hospital de S. João, Porto.
Abstract:
The authors studied the relative prevalence of erythroid cytoskeletal protein defects and their relationship with the clinical course of Hereditary Spherocytosis (HS) in 39 Portuguese patients of North of Portugal (25 families). This study showed that, in the North of Portugal, HS is primarily due to anquirin deficiency (72%), followed by band 3 (20%). These findings are similar to the published data in other Caucasian populations. Anquirin primary defects have been difficult to diagnose before splenectomy, due to high reticulocytes counts.
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